Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 11/09/21 08:30 | 11/09/21 08:29 | Crystal Palace | Tottenham Hotspurs | 3:0 | 2 - 4 pontos |
| 11/09/21 11:00 | 11/09/21 10:59 | Brentford FC | Brighton and Hove Albion | 0:1 | 2 - 4 pontos |
| 11/09/21 11:00 | 11/09/21 10:59 | Leicester City | Manchester City | 0:1 | 2 - 4 pontos |
| 11/09/21 11:00 | 11/09/21 10:59 | Manchester United | Newcastle United | 4:1 | 2 - 4 pontos |
| 11/09/21 11:00 | 11/09/21 10:59 | FC Southampton | West Ham United | 0:0 | 2 - 4 pontos |
| 11/09/21 11:00 | 11/09/21 10:59 | FC Arsenal | Norwich City | 1:0 | 2 - 4 pontos |
| 11/09/21 11:00 | 11/09/21 10:59 | FC Watford | Wolverhampton Wanderers | 0:2 | 2 - 4 pontos |
| 11/09/21 13:30 | 11/09/21 13:29 | FC Chelsea | Aston Villa | 3:0 | 2 - 4 pontos |
| 12/09/21 12:30 | 12/09/21 12:29 | Leeds United | FC Liverpool | 0:3 | 2 - 4 pontos |
| 13/09/21 16:00 | 13/09/21 15:59 | FC Everton | FC Burnley | 3:1 | 2 - 4 pontos |