Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 05/11/21 17:00 | 05/11/21 16:59 | FC Southampton | Aston Villa | 1:0 | 2 - 4 pontos |
| 06/11/21 09:30 | 06/11/21 09:29 | Manchester United | Manchester City | 0:2 | 2 - 4 pontos |
| 06/11/21 12:00 | 06/11/21 11:59 | Brentford FC | Norwich City | 1:2 | 2 - 4 pontos |
| 06/11/21 12:00 | 06/11/21 11:59 | FC Chelsea | FC Burnley | 1:1 | 2 - 4 pontos |
| 06/11/21 12:00 | 06/11/21 11:59 | Crystal Palace | Wolverhampton Wanderers | 2:0 | 2 - 4 pontos |
| 06/11/21 14:30 | 06/11/21 14:29 | Brighton and Hove Albion | Newcastle United | 1:1 | 2 - 4 pontos |
| 07/11/21 11:00 | 07/11/21 10:59 | FC Arsenal | FC Watford | 1:0 | 2 - 4 pontos |
| 07/11/21 11:00 | 07/11/21 10:59 | FC Everton | Tottenham Hotspurs | 0:0 | 2 - 4 pontos |
| 07/11/21 11:00 | 07/11/21 10:59 | Leeds United | Leicester City | 1:1 | 2 - 4 pontos |
| 07/11/21 13:30 | 07/11/21 13:29 | West Ham United | FC Liverpool | 3:2 | 2 - 4 pontos |